[China Instrument Network Instrument Research and Development] On July 18, it was learned from the Southern University of Science and Technology that Chinese and American scientists recently jointly published a paper published in BioRxiv, an internationally renowned biological preprinting journal. It demonstrated for the first time the use of Guangdong Shenzhen Bohai Gene Technology Co., Ltd. GenoCare. The third-generation single-molecule sequencer completed the genome sequencing of E. coli, with an accuracy rate of 99.7%. It is the third-generation gene sequencer with the highest accuracy.
This international-level major scientific and technological achievement was jointly completed by Southern University of Science and Technology, Rice University of America, Beijing Genomics Institute and Bohai Gene Company. The authors compared the sequencing data of E. coli with the American Illumina II sequencer currently occupying the majority of the market and the GenoCare III sequencer of Bohai. The results showed that the GenomeCare III sequencer genome consistency with the Illumina sequencer reached 99%.
Guangdong Shenzhen Bohai Gene Technology Co., Ltd. was founded in 2012 by Dr. He Jiankui, an 80-year-old professor from Nanke University who was only 30 years old. He has led a team of top scientists in the field of gene sequencing and led a team of doctoral foreign students from Stanford University and the University of Michigan. A strong core technical team has received support from the government and venture capital agencies.
Through understanding, the core technology of GenoCare's third-generation gene sequencer is single-molecule fluorescence sequencing, which reduces the difficulty of the experiment and greatly reduces the cost of gene sequencing. It has great advantages in clinical use.
With this "strange technique", the universal sequencing kit independently developed by Bohai Gene has successfully completed the registration and approval of the first type of medical devices, becoming the first three-generation single-molecule sequencing system kit registered through the registration of Chinese medical devices.
A DNA fragment with a genetic message is called a gene, and gene sequencing refers to an arrangement for analyzing the base sequence of a specific DNA fragment. According to Dr. He Jiankui, testing complete genome sequence of E. coli can enable researchers to understand the characteristics of the pathogen even more, and even track and treat future outbreaks.
Dr. He Jiankui said that he would strive to reduce the cost of sequencing a human genome to 100 US dollars by 2019, so that ordinary people can have their own "gene ID card."
According to its introduction, GenoCare third-generation single-molecule sequencer can be used in prenatal screening, preimplantation genetic screening, cancer, neonatal (single-gene disease screening, genetic disease screening), single cell sequencing, etc. Currently, there are more than 700 orders.
(Original Title: The 80th Postgraduate Team of NUS University Developed the World's Most Qualified Third Generation Gene Sequencer)