Recently, the State Key Laboratory of Molecular Reaction Dynamics of the Institute of Chemistry, Chinese Academy of Sciences has successfully developed an interface with subwavenumber resolution (<1cm-1) under the support of the National Key Research Institute of Natural Science Funds. Frequency vibration spectroscopy system. 
High-resolution broadband sum frequency generation vibrational spectroscopy (HR-BB-SFG-VS) is a frontier spectroscopy technique for the study of intermolecular interactions.
The instrument's final test index meets or exceeds the original design parameters. The FWHM of a femtosecond infrared pulse is greater than 250 wavenumbers. It can cover an infrared range of more than 400 wave numbers at a time. The spectral resolution reaches 0.4 wave numbers, which is better than the parameters of the same type of equipment that have been reported in the world. The spectral resolution of the 10-20 wavenumbers of the frequency spectrum has been greatly improved.
The instrument can be used to measure the molecular vibrational spectrum, molecular orientation structure and dynamics of the gas-liquid interface, gas-solid interface, supramolecular chiral interface, and biofilm interface.
Sphingolipid molecules are an important part of the plasma membrane. The interaction between Ca2+ and sphingomyelin has always been a research topic in the life sciences.
The researchers used the developed high-resolution broadband and frequency-frequency vibration spectroscopy to study the effect of Ca2+ on the structure and orientation of the monolayer of sphingomyelin (ESM) monolayer, and proposed the molecular mechanism of interaction between Ca2+ and ESM ( Figure 1) provides an experimental basis for an in-depth understanding of the molecular mechanisms of neuronal signal transduction and the mechanism of the effects of electrolytes on neurotransmission in vivo.
This work is the world's first high-resolution broadband and frequency-frequency vibration spectroscopy study of phospholipid systems, demonstrating the ability of the technology to study complex systems. The relevant research results were recently published in Biophysical Journal, Volume 112, Issue 10, 2017, p2173–2183, and were recommended by the editor as Featured Article.
(Original title: The Institute of Chemistry successfully developed a high resolution broadband and frequency vibration spectrometer)
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